Methods	Multicentre, randomised, double-blind, parallel-group. Single oral dose Medication taken when migraine headache pain was of moderate or severe intensity Assessments at 0, 2 and 24 hours.
Participants	Aged 18 to 65 years, meeting IHS criteria for migraine. Excluded attacks of migraine with aura. Excluded participants with tension headache N = 303 M = 35, F = 268 Mean age = 40 years
Interventions	Effervescent aspirin 900 mg plus metoclopramide 10 mg, n = 152 Placebo, n = 151
Outcomes	Headache relief at 2 hours Pain-free at 2 hours 24-hour sustained relief Use of rescue medication Relief of associated symptoms Functional disability PGE Adverse events
Notes	Oxford Quality Score: R1, DB1, W1. Total = 3.
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Unclear	“Patients were randomised after drawing lots”
Allocation concealment?	Unclear	Not described
Blinding? All outcomes	Unclear	Not described