Methods	Multicentre, randomised, double-blind, three parallel groups. Single oral dose per attack. Two attacks treated Medication taken when migraine headache pain of moderate or severe intensity Assessments at 0 and 2 hours. If pain not controlled, participants asked to wait 2 hours before taking rescue medication
Participants	Aged 18-65 years, meeting IHS criteria for migraine with or without aura. At least 12-month history of migraine, with two to six attacks per month during three months prior to study N = 421 (385 experienced ≥1 attack and analysed for efficacy) M = 94, F = 327 Mean age = 39 years
Interventions	Lysine acetylsalicylate 1620 mg (equivalent to 900 mg aspirin) plus metoclopramide 10 mg, n = 137 Sumatriptan 100 mg, n = 122 Placebo, n = 126
Outcomes	Headache relief at 2 hours PI: 4-point scale Pain-free at 2 hours 24-hour sustained relief Headache recurrence at 24 hours Relief of nausea and vomiting Use of rescue medication PGE: 4-point scale Adverse effects
Notes	Oxford Quality Score: R1, DB2, W1. Total = 4.
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Unclear	Not described
Allocation concealment?	Unclear	Not described
Blinding? All outcomes	Yes	Double dummy design