Methods	Multicentre, randomised, double-blind, parallel-group. Medication taken up to three times at 2-hour intervals, if adequate relief not obtained, to treat a single migraine attack Rescue medication taken if no relief of symptoms after three doses of trial medication. Usual medication allowed if attack persisted 2 hours after second dose of trial medication Assessments at 0 and 2 hours.
Participants	Aged 18-65 years, meeting IHS criteria for migraine. Excluded participants with tension headache. N = 227 M = 34, F = 193 Mean age 34 years
Interventions	Lysine acetylsalicylate 1620 mg (equivalent to 900 mg aspirin) plus metoclopramide 10 mg, n = 112 Ergotamine 2 mg plus caffeine 200 mg, n = 115
Outcomes	No nausea or vomiting 2 hours after first intake Headache intensity (4-point categorical scale) Headache relief Complete resolution of headache Use of rescue medication Patients’ global evaluation of treatment
Notes	Oxford Quality Score: R2, DB2, W1. Total = 5.
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Yes	“Central randomisation list generated with SAS (PC version) 6.08”
Allocation concealment?	Unclear	Not described
Blinding? All outcomes	Yes	“Maintained by providing an equivalent number of placebo sachets or capsules”