Comparison 5.

Aspirin ± metoclopramide versus placebo

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Use of rescue medication	8	2922	Risk Ratio (M-H, Fixed, 95% CI)	0.68 [0.63, 0.72]
1.1 Aspirin 100 mg alone	5	1881	Risk Ratio (M-H, Fixed, 95% CI)	0.67 [0.61, 0.73]
1.2 Aspirin 900 mg + metoclopramide 10 mg	3	1041	Risk Ratio (M-H, Fixed, 95% CI)	0.69 [0.62, 0.77]
2 Any adverse event within 24 hours	7	2458	Risk Ratio (M-H, Fixed, 95% CI)	1.26 [1.02, 1.55]
2.1 Aspirin alone	5	1892	Risk Ratio (M-H, Fixed, 95% CI)	1.30 [1.00, 1.68]
2.2 Aspirin + metoclopramide	2	566	Risk Ratio (M-H, Fixed, 95% CI)	1.17 [0.82, 1.67]