| Study ID | Treatment | HR 1 h | HR 2 h | PF 2 h | 24 h SHR | 24 h SPF | Use of rescue medication |
|---|---|---|---|---|---|---|---|
| Boureau 1994 | (1) Aspirin 1000 mg, n = 198 (2) Paracetamol 400 mg + codeine 25 mg, n = 198 (3) Placebo, n = 198 |
No data | (1) 104/198 (2) 98/198 (3) 59/198 |
(1) 36/198 (2) 44/198 (3) 22/198 |
No data | No data | (1) 110/198 (2) 100/198 (3) 148/198 |
| Chabriat 1994 | (1) LAS 1650 mg (= 900 mg aspirin) + metoclopramide 10 mg, n = 126 (2) Placebo, n = 124 |
No data | 1st attack (1) 74/126 (2) 36/124 |
No usable data - denominator unclear | No usable data - total attacks | No data | Total attacks (1) 111/237 (2) 162/238 |
| Diener 2004a | (1) Effervescent aspirin 1000 mg, n = 147 (2) Sumatriptan 50 mg, n = 135 (3) Placebo, n = 153 |
(1) 62/146 (2) 31/135 (3) 23/152 |
(1) 72/146 (2) 66/135 (3) 50/152 |
(1) 37/146 (2) 33/135 (3) 22/152 |
(1) 48/146 (2) 47/135 (3) 33/152 |
No data | (1) 62/146 (2) 53/135 (3) 98/152 |
| Diener 2004b | (1) Effervescent aspirin 1000 mg, n = 222 (2) Ibuprofen 400 mg, n = 212 (3) Sumatriptan 50 mg, n = 226 (4) Placebo, n = 222 |
(1) 76/221 (2) 65/211 (3) 54/224 (4) 25/222 |
(1) 116/221 (2) 127/211 (3) 125/224 (4) 68/222 |
(1) 60/221 (2) 70/221 (3) 83/224 (4) 28/222 |
(1) 93/221 (2) 103/211 (3) 96/224 (4) 56/222 |
No data | (1) 99/221 (2) 87/211 (3) 92/224 (4) 147/222 |
| Geraud 2002 | (1) Aspirin 900 mg + metoclopramide 10 mg, n = 340 (2) Zolmitriptan 2.5 mg, n = 326 |
No data | 1st attack (1) 226/340 (2) 197/326 |
No usable data - average over 3 attacks | No usable data - denominator unclear | No data | Overall use: (1) 255/949 (2) 229/909 |
| Henry 1995 | (1) Effervescent aspirin 900 mg + metoclopramide 10 mg, n = 152 (2) Placebo, n = 151 |
No data | (1) 69/127* (2) 34/131* |
(1) 18/127 (2) 7/131 |
No usable data - denominator unclear | No data | (1) 66/152 (2) 91/151 |
| Lange 2000 | (1) Effervescent acetylsalicylic acid 1000 mg, n = 169 (2) Placebo, n = 174 |
No data | (1) 93/169 (2) 64/174 |
(1) 49/169 (2) 29/174 |
No data | No data | (1) 65/169 (2) 100/174 |
| Le Jeunne 1998 | (1) calcium carbasalate (= 900 mg aspirin) plus metoclopramide 10 mg, n = 134 (2) ergotamine tartrate 1 mg plus caffeine 100 mg, n = 132 |
No data | 1st attack (1) 73/134 (2) 48/132 |
1st attack (1) 27/134 (2) 11/132 |
1st attack (1) 61/73 (2) 44/48 |
No data | 1st attack (1) 49/134 (2) 61/131 |
| Lipton 2005 | (1) Aspirin 1000 mg, n = 205 (2) Placebo, n = 204 |
(1) 68/201 (2) 36/200 |
(1) 105/201 (2) 68/200 |
(1) 40/201 (2) 12/200 |
(1) 82/201 (2) 49/200 |
No data | (1) 68/201 (2) 104/200 |
| MacGregor 2002 | (1) Mouth-dispersible aspirin 900 mg, n = 73 (2) Placebo, n = 73 |
(1) 30/73 (2) 15/73 |
(1) 35/73 (2) 14/73 |
(1) 10/73 (2) 4/73 |
No usable data - recurrence less with aspirin | No usable data | No usable data - less with aspirin |
| Tfelt-Hansen 1995 | (1) LAS 1620 mg (= 900 mg aspirin) + metoclopramide 10 mg, n = 137 (2) Sumatriptan 100 mg, n = 122 (3) Placebo, n = 126 |
No data | 1st attack (1) 76/133 (2) 63/119 (3) 30/124 |
1st attack (1) 29/135 (2) 36/122 (3) 10/126 |
1st attack (1) 49/133 (2) 39/119 (3) 21/124 |
No data | 1st attack (1) 74/137 (2) 77/122 (3) 102/126 |
| Thomson 1992 | (1) Aspirin 900 mg + metoclopramide 10 mg, n = 183 (2) Sumatriptan 100 mg, n = 175 |
No data | 1st attack, in pts with mod/sev pain (1) 62/138 (2) 74/133 |
1st attack (1) 19/138 (2) 35/133 |
No usable data - data for 48 h | No data | 1st attack (1) 102/183 (2) 59/175 |
| Titus 2001 | (1) LAS 1620 mg (= 900 mg aspirin) + metoclopramide 10 mg, n = 125 (2) Ergotamine 2 mg + caffeine 200 mg, n = 121 |
No data | No usable data | No usable data | No usable data | No usable data | No usable data |
*
25 aspirin + metoclopramide and 20 placebo participants asleep
HR - headache relief; LAS - lysine acetylsalicylate; PF - pain-free; SHR - sustained headache relief; SPF - sustained pain-free