Methods	Multicentre, randomised, double-blind, placebo-controlled, parallel-group. Single oral dose per attack. Participants treated two migraine attacks Medication taken when migraine headache pain of moderate or severe intensity Assessments at 0 and 2 hours. If pain not controlled, participants asked to wait 2 hours before taking rescue medication
Participants	Aged 18-65 years, meeting IHS criteria for migraine with or without aura. At least 12-month history of migraine, with two to six attacks per month for three months prior to inclusion in study. Prophylaxis permitted if stable for ≥3 months Excluded participants whose migraine headache was never accompanied by nausea or vomiting N = 266 (250 analysed for efficacy, 16 did not take medication) M = 46, F = 220 Mean age 37 years
Interventions	Lysine acetylsalicylate 1650 mg (equivalent to 900 mg aspirin) plus metoclopramide 10 mg, n = 126 Placebo, n = 124
Outcomes	Headache relief at 2 hours Pain-free at 2 hours PI: 4-point scale Presence of nausea and vomiting Headache recurrence at 24 hours PGE: 4-point scale Use of rescue medications
Notes	Oxford Quality Score: R1, DB1, W1. Total = 3.
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Unclear	Not described
Allocation concealment?	Unclear	Not described
Blinding? All outcomes	Unclear	Not described