. Author manuscript; available in PMC: 2015 Oct 1.

Published in final edited form as: Am J Cardiol. 2014 Jul 16;114(7):997–1002. doi: 10.1016/j.amjcard.2014.07.009

Table 4. Risk of cardiovascular events by physical limitation entered as a continuous variable.

	Hospitalization for Angina		Revascularization		Myocardial Infarction		Heart Failure		Death
	HR (95%CI)^a	P- value	HR (95%CI)^a	P- value	HR (95%CI)^a	P- value	HR (95%CI)^a	P- value	HR (95%CI)^a	P- value
Unadjusted	1.4 (1.2, 1.6)	<.001	1.2 (1.1, 1.4)	0.001	1.2 (1.1, 1.4)	0.003	1.5 (1.4, 1.7)	<.001	1.3 (1.2, 1.4)	<.001
Model 1 ^b	1.3 (1.1, 1.4)	0.001	1.2 (1.0, 1.4)	0.008	1.1 (1.0, 1.3)	0.11	1.4 (1.2, 1.6)	<.001	1.3 (1.2, 1.4)	<.001
Model 2 ^c	1.3 (1.1, 1.4)	0.001	1.2 (1.0, 1.4)	0.02	1.2 (1.0, 1.4)	0.09	1.3 (1.2, 1.6)	<.001	1.3 (1.2, 1.5)	<.001
Model 3 ^d	1.2 (1.1, 1.4)	0.004	1.2 (1.0, 1.4)	0.03	1.1 (0.9, 1.3)	0.46	1.2 (1.0, 1.4)	0.04	1.1 (1.0, 1.3)	0.01

Hazard Ratio (HR) and 95% confidence interval (CI) for cardiovascular events per 20 unit decrease (worsening) in Seattle Angina Questionnaire Physical Limitation scale (1-100)

Model 1 adjusts for age, sex, smoking, hypertension history, heart failure history, body mass index, diastolic blood pressure, beta-blocker use, calcium-channel blocker use, and nitrate use.

Model 2 adjusts for the factors in Model 1 + depressive symptoms.

Model 3 adjusts for the factors in Model 2 + treadmill exercise capacity, left ventricular ejection fraction, and inducible ischemia.