Table 1.
Characteristics of the transplant cohort (n=1,052), by transplant period.
| Characteristics | Early Period (2000-2005) N (%) | Recent Period (2006-2011) N (%) | P value |
|---|---|---|---|
| Total N = 356 | Total N = 696 | ||
| Age | <0.01 | ||
| Median age, years (range) | 46 (19-71) | 52(18-73) | |
| Sex | 0.48 | ||
| Male | 154 (43) | 284 (41) | |
| Female | 202 (57) | 412 (59) | |
| Diagnosis | <0.01 | ||
| Acute leukemia/MDS | 211 (59) | 397 (57) | |
| CML | 27 (8) | 18 (3) | |
| Lymphoma/CLL | 87 (24) | 217 (31) | |
| Multiple myeloma | 11 (3) | 52 (7) | |
| Other1 | 20 (6) | 12 (2) | |
| Donor Type | <0.01 | ||
| Matched related | 198 (56) | 245 (35) | |
| Matched unrelated | 89 (25) | 228 (33) | |
| Mismatched 2 | 69 (19) | 223 (32) | |
| Stem cell source | <0.01 | ||
| Bone marrow | 105 (29) | 26 (4) | |
| Peripheral blood | 251 (71) | 565 (81) | |
| Umbilical cord blood | 0 | 105 (15) | |
| T-cell Depletion | <0.01 | ||
| No | 116 (33) | 356 (51) | |
| Yes | 240 (67) | 340 (49) | |
| Conditioning | <0.01 | ||
| Myeloablative | 222 (62) | 325 (47) | |
| Reduced intensity | 67 (19) | 216 (31) | |
| Non-myeloablative | 67 (19) | 155 (22) |
Continuous variables are displayed as mean (range), categorical variables are displayed as N (%).
1
Other: Myeloproliferative disorder, solid tumor, non-malignant hematologic disorder.
2
related or unrelated.
Abbreviations: MDS: myelodysplastic syndrome; CML: chronic myeloid leukemia; CLL: chronic lymphocytic leukemia.