Table 5.
Incidence of pre-engraftment bacteremia and Hazard Ratio (95% CI) of antibiotic prophylaxis for specific pathogens.
| Antibiotic Prophylaxis | Overall | Viridans Streptococci1 | Enterococci2 | Staphylococci1 | GNR3 | |
|---|---|---|---|---|---|---|
| None | Incidence | 27.6 | 15.8 | 6.2 | 5.6 | 7.9 |
| Univariate | Reference | Reference | Reference | Reference | Reference | |
| Multivariate | Reference | Reference | Reference | Reference | Reference | |
| Vancomycin only | Incidence | 16.3 | 0 | 6.1 | 1.1 | 9.5 |
| Univariate | 0.57 (0.40 - 0.81)* | NA | 0.93 (0.47 - 1.83) | 0.19 (0.07 - 0.53)* | 1.19 (0.66 - 2.14) | |
| Multivariate | 0.46 (0.30 - 0.72)* | NA | 0.92 (043 - 200) | 0.14 (0.04 - 0.52)* | 0.89 (0.43 - 1.85) | |
| Vancomycin+FQ | Incidence | 11.6 | 0 | 7.5 | 0.6 | 4.1 |
| Univariate | 0.42 (0.28 - 0.64)* | NA | 1.17 (0.58 - 2.37) | 0.10 (0.02 - 0.48)* | 0.54 (0.26 - 1.12) | |
| Multivariate | 0.31 (0.19 - 0.53)* | NA | 1.07 (0.47 - 2.44) | 0.07 (0.01 - 0.43)* | 0.35 (0.15 - 0.85)* | |
| FQ only | Incidence | 23.3 | 2.1 | 6.4 | 8.5 | 6.4 |
| Univariate | 0.83 (0.43 - 1.59) | 0.13 (0.02-0.98) | 0.98 (0.27 - 3.52) | 1.47 (0.46 - 4.70) | 0.80 (0.23 - 2.79) | |
| Multivariate | 0.67 (0.33 - 1.37) | 0.17 (0.02-1.50) | 1.01 (0.27 - 3.80) | 1.07 (0.26 - 4.46) | 0.60 (0.16 - 2.24) | |
Hazard ratios from univariate and multivariate analysis are displayed as Hazard Ratio and 95% confidence interval (95% CI) in the table. Antibiotic prophylaxis: ≥ 1 dose of antibiotic starting between day −2 to +2 of stem cell infusion. No patient who received vancomycin or vancomycin with fluoroquinolone prophylaxis developed bacteremia from viridans streptococci; hence, no hazard ratio could be calculated. Incidence was per 1,000 patient-days at risk. No prophylaxis (None) was considered the reference group; NA: not available; GNR: gram-negative rods.
Notes: Stepwise model selection with 0.3 as significance level to enter and 0.1 as significant level to be retained in the model.
multivariate model adjusted for transplant periods.
multivariate model adjusted for age, stem cell source, T-cell depletion, and, transplant periods.
multivariate model adjusted for stem cell source, T-cell depletion, and, transplant period.
*one asterisk means statistically significant (P<0.01).