Table 1. Examples of direct cross-regulation among lncRNAs and miRNAs.

LncRNAs (column 1) affecting the levels and/or activity of microRNAs (column 2) and vice versa are summarized (column 3); if known, the consequences on gene expression are also indicated (column 4).

lncRNA	microRNA	Interplay	Consequences	References
lincRNA-p21	let-7b	lncRNA decay	Translational repression of JUNB and CTNNB mRNAs	[42]
HOTAIR	let-7i	lncRNA decay	Ataxin-1 and Snurportin-1 ubiquitination	[45]
	miR-34a	lncRNA decay	Tumorigenesis	[47]
MALAT1	miR-9	lncRNA decay	Repression of MALAT1	[48]
LOC285194	miR-211	lncRNA decay	Tumorigenesis	[49]
PTCSC3	miR-574-5p	lncRNA decay	Tumorigenesis Proliferation	[50]
H19	let7a,b,g,i	lncRNA decay, decoy	Decay of let-7 target mRNAs in muscle cells	[51]
	miR-675	miRNA production	Proliferation, myogenesis	[67,69]
lincRNA-RoR	miR145-5p miR-181a-5p miR-99b-3p	lncRNA decay miRNA competition lncRNA decay lncRNA decay	Stability of Nanog, Oct4, and Sox2 mRNAs	52]
Linc-MD1	miR-133 miR-135 miR-206 miR-133b	miRNA competition miRNA competition miRNA production miRNA production	Muscle differentiation, and abundance of MAML1 and MEF2C mRNAs	[57]
CDR1as/ciRS-7	miR-7	miRNA sponge	Neuronal function	[60]
Sry	miR-138	miRNA sponge		[59]
BACE1AS	miR-485-5p	miRNA competition	Brain	[66]
ncNRFR	let-7b,c,d,e,f,g,i miR-98	miRNA competition miRNA competition	Tumorigenesis	[67]
RMRP	RMRP-S1 RMRP-S2	miRNA production miRNA production	CHH (Cartilage-hair hypoplasia) disease	[70]