Medically relevant fungi, syndromes, and murine models of disease.
A, The schematic depicts the primary anatomic sites commonly affected by medically relevant fungal diseases in humans. Most fungal diseases are acquired when infectious particles are inhaled, inoculated via trauma, or penetrate breaches in mucosal integrity. Common sites of fungal dissemination (diss.) are indicated. B, The schematic depicts common routes of fungal administration in vertebrate models of disease. Specific features and experimental considerations associated with each infection route are indicated.