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. Author manuscript; available in PMC: 2015 Sep 11.
Published in final edited form as: Cell Rep. 2014 Aug 28;8(5):1339–1346. doi: 10.1016/j.celrep.2014.08.002

Figure 1. Experimental design for analysis of cell of origin.

Figure 1

The inducible CK5-CreERT2 driver can lineage-mark basal cells by YFP expression in different prostate cancer models prior to overt cancer formation. Similarly, the inducible PSA-CreERT2 and CK8-CreERT2 drivers can mark luminal cells in phenotypically normal epithelium. The presence of YFP+ cell clusters in subsequent PIN/cancer lesions indicates that the marked cell type acts as the cell of origin in the mouse model analyzed.