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. 2014 Aug 27;11:152. doi: 10.1186/1743-422X-11-152

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© He et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Halo-FISH analysis of acutely SIV-infected C8166 T cells. Integration of SIV into the genomic DNA of the C8166 T cell line. Three acutely SIV-infected cells were shown in three different rows. Halo-FISH analyses of cells 1 d after acute infection was performed by using a SIV gag-env DNA probe. Nuclei were visualized by DAPI staining. Single integration events of SIV proviral DNA (SIV probe, white spots; Merged with DAPI staining, red spots) into the nuclear matrix at regions of high transcriptional activity (blue sphere) are clearly visible. No integration into the associated HALO (regions of low transcriptional activity surrounding the nuclear matrix) was observed.