Table 1.
Comparison of viral load in lytic versus chronic infection of CD4 + T cell line C8166
| SIV mac251/C8166 | Lytic infection | Chronic infection |
|---|---|---|
| Percentage of infected cells1 | 25% | 100% |
| Copy number2 | 0.3 | 2-3 |
| Viruses in supernatant3 | 3 | 300 |
| Provirus integration4 | 18% | n.d.5 |
1As determined by indirect immune peroxidase assay.
2Copies per SIV DNA as determined by proviral specific PCR.
3Particles per cell at one day after infection or medium exchange by means of PCR analysis.
4Halo-FISH analysis, integration into transcriptionally active matrix regions.
5 n.d. not detectable by Halo-FISH analysis.