Figure 4.
Representative images show urine spots of mice treated with saline, acrolein, acrolein plus GP1a and acrolein plus AM630 plus GP1a at 24 hours after saline or acrolein instillation (A). Scale bar indicates 2 cm. Number of spots increased after acrolein intravesical instillation. Acrolein effect was attenuated by GP1a and GP1a effect was reversed by selective antagonist AM630 (B). Values represent mean ± SEM of 6 saline treated controls and 8 mice with other treatment. Asterisk indicates p <0.05 vs saline. Pound sign indicates p <0.05 vs acrolein and vs acrolein plus AM630 plus GP1a.