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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Semin Nephrol. 2014 Jun 13;34(4):418–428. doi: 10.1016/j.semnephrol.2014.06.008

Table 1.

Summary of published studies on parietal epithelial cells as adult podocyte progenitors

Model System Supporting Data Reference
Studies strongly supporting PECs as podocyte progenitors PEC reporter mouse

  • A subset of labeled PECs are detected in the glomerular tuft in newborn and adolescent mice and co-express podocyte markers

 49
51
Human kidney

  • A subpopulation of PECs at tubular pole co-stain for the stem/progenitor markers CD133/CD24

  • When these cells are isolated, and grown ex vivo, they have self-renewal potential and high cloning efficiency

  • Under certain culture conditions they acquire podocyte phenotypic features

  • Cells harvested from normal kidneys that double-labeled for PEC and stem/progenitor markers improved disease outcomes when injected into mice with experimental FSGS

  • Ultrastructure?

 54
48
53
Studies suggesting, but not definitively proving, that a subset of PECs are adult podocyte progenitors Rat model

  • ACE-inhibition affects a subset of cells lining Bowman’s capsule that co-express PEC proteins and NCAM (used as a differentiation marker)

 19
Diabetic mouse

  • Blockade of the chemokine stromal-derived factor (SFD/CXCL12) enhanced the differentiation of renal progenitors towards a podocyte phenotype

 55