Table-III.
Cox regression analysis of VEGF polymorphisms with the PFS and OS of osteosarcoma patients
| Genotype |
PFS
|
HR (95%CI) 1 | P value |
OS
|
HR (95%CI) 1 | P value | |||
|---|---|---|---|---|---|---|---|---|---|
| Event | % | Event | % | ||||||
| +1612A/G | GG | 66 | 38.60 | 1.0(Ref.) | - | 45 | 38.79 | 1.0(Ref.) | - |
| GA | 76 | 44.44 | 0.72(0.39-1.35) | 0.28 | 51 | 43.97 | 0.8(0.45-1.43) | 0.42 | |
| AA | 29 | 16.96 | 0.56(0.25-1.24) | 0.12 | 20 | 17.24 | 0.71(0.33-1.51) | 0.34 | |
| A allele | 208 | 60.82 | 1.0(Ref.) | - | 141 | 60.78 | 1.0(Ref.) | - | |
| G allele | 134 | 39.18 | 0.74(0.50-1.08) | 0.1 | 91 | 39.22 | 0.83(0.57-1.19) | 0.29 | |
| -634G/C | CC | 68 | 39.77 | 1.0(Ref.) | - | 45 | 38.79 | 1.0(Ref.) | - |
| CT | 86 | 50.29 | 0.69(0.38-1.26) | 0.2 | 59 | 50.86 | 0.86(0.49-1.50) | 0.56 | |
| TT | 17 | 9.94 | 0.58(0.23-1.53) | 0.22 | 11 | 9.48 | 0.69(0.27-1.75) | 0.4 | |
| C allele | 222 | 64.91 | 1.0(Ref.) | - | 149 | 64.22 | 1.0(Ref.) | - | |
| T allele | 120 | 35.09 | 0.48(0.31-0.72) | <0.001 | 81 | 34.91 | 0.66(0.45-0.97) | 0.03 | |
| +936T/C | TT | 100 | 58.48 | 1.0(Ref.) | - | 69 | 59.48 | 1.0(Ref.) | - |
| TC | 59 | 34.50 | 0.66(0.36-1.19) | 0.13 | 40 | 34.48 | 0.75(0.43-1.31) | 0.28 | |
| CC | 12 | 7.02 | 0.32(0.13-0.81) | 0.006 | 7 | 6.03 | 0.36(0.12-0.96) | 0.03 | |
| T allele | 259 | 75.73 | 1.0(Ref.) | - | 178 | 76.72 | 1.0(Ref.) | - | |
| C allele | 83 | 24.27 | 0.56(0.37-0.85) | 0.004 | 54 | 23.28 | 0.63(0.42-0.95) | 0.02 | |
1. Adjusted for sex, age, tumor location, metastasis and therapy.