Table 2.
Pharmacokinetic parameters of berberine and palmatine in rat after oral administration of Rhizoma Coptidis extract at a dose of 96 mg/kg (mean ± SD, n = 5).
| Parameters | Berberine | Palmatine | ||
|---|---|---|---|---|
| Control | Model | Control | Model | |
| T 1/2,λz (min) | 945.8 ± 349.5 | 836.2 ± 253.3 | 1611.7 ± 616.0 | 1521.7 ± 710.9 |
| T max (min) | 15.0 ± 0.0 | 15.0 ± 0.0 | 15.0 ± 0.0 | 15.0 ± 0.0 |
| C max (ng/mL) | 20.0 ± 12.1 | 39.2 ± 7.9∗∗ | 8.1 ± 2.2 | 9.1 ± 1.2 |
| AUC0–t (min·ng/mL) | 4954.3 ± 784.3 | 9874.7 ± 2713.1∗∗ | 1470.6 ± 229.8 | 2186.6 ± 693.4∗ |
| V d/F λz (L/kg) | 5124.3 ± 1841.2 | 2503.9 ± 542.4∗∗ | 4869.6 ± 1237.6 | 4315.9 ± 1111.3 |
| CL/F (L/h/kg) | 198.6 ± 75.4 | 124.3 ± 27.4∗ | 147.4 ± 45.3 | 119.3 ± 28.1 |
**P < 0.01 and ∗P < 0.05 compared with the control group.