Table 3.
Levels of lipids (mg/dL) according to genotypes and alleles of LPL and of apoE in individuals exposed to Leishmania infantum.
| Polymorphisms | Age | Lipids (mg/dL) | ||||||
|---|---|---|---|---|---|---|---|---|
| TCa | LDL-Ca | HDL-Ca | TAGa | VLDL-Ca | ||||
| HindIII | Genotypes | H+/H+ (n = 19) | 22.6 ± 15.4 | 150.8 ± 42.2 | 91.0 ± 44.0 | 38.1 ± 5.6 | 207.6 ± 82.7 | 41.5 ± 16.5 |
| H+/H− (n = 33) | 22.1 ± 18.2 | 138.8 ± 34.8 | 77.4 ± 35.6 | 41.9 ± 6.4 | 157.9 ± 52.8 | 31.6 ± 10.5 | ||
| P value# | 0.914 | 0.274 | 0.228 | 0.037 | 0.011 | 0.010 | ||
| Alleles | H+ (n = 71) | 22.4 ± 16.6 | 145.3 ± 38.8 | 84.7 ± 40.3 | 39.9 ± 6.2 | 184.5 ± 73.6 | 36.9 ± 14.6 | |
| H− (n = 37) | 22.7 ± 17.5 | 135.2 ± 34.7 | 74.4 ± 34.7 | 42.5 ± 6.3 | 154.5 ± 50.8 | 30.9 ± 10.1 | ||
| P value# | 0.919 | 0.187 | 0.191 | 0.040 | 0.029 | 0.029 | ||
|
| ||||||||
| PvuII | Genotypes | P1/P1 (n = 15) | 22.4 ± 14.0 | 24.6 ± 16.7 | 81.7 ± 37.1 | 40.0 ± 4.7 | 159.4 ± 50.9 | 31.9 ± 10.1 |
| P1/P2 (n = 27) | 24.6 ± 16.7 | 141.8 ± 38.7 | 84.3 ± 39.7 | 39.9 ± 6.3 | 173.0 ± 77.7 | 34.6 ± 15.5 | ||
| P2/P2 (n = 4) | 16.5 ± 17.8 | 132.8 ± 40.3 | 71.7 ± 28.8 | 41.5 ± 5.7 | 230.5 ± 89.0 | 46.0 ± 17.6 | ||
| Pvalue§ | 0.622 | 0.878 | 0.828 | 0.878 | 0.217 | 0.220 | ||
| Alleles | P1 (n = 57) | 23.5 ± 15.1 | 142.8 ± 36.5 | 82.9 ± 37.7 | 40.0 ± 5.4 | 165.8 ± 64.4 | 165.8 ± 64.4 | |
| P2 (n = 35) | 22.8 ± 16.7 | 139.7 ± 38.1 | 81.4 ± 37.1 | 40.3 ± 6.1 | 186.1 ± 81.4 | 37.2 ± 16.2 | ||
| P value# | 0.840 | 0.706 | 0.853 | 0.793 | 0.188 | 0.191 | ||
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| ||||||||
| apoE | Genotypes | E2/E3 (n = 4) | 23.7 ± 14.3 | 120.0 ± 36.2 | 65.7 ± 30.4 | 41.7 ± 7.8 | 275.3 ± 113.5∗,†l | 54.7 ± 22.7∗,† |
| E3/E3 (n = 29) | 19.1 ± 14.8 | 152.1 ± 40.1 | 91.5 ± 41.6 | 39.2 ± 5.8 | 166.9 ± 58.5 | 33.4 ± 11.6 | ||
| E3/E4 (n = 6) | 35.5 ± 18.1 | 119.0 ± 11.9 | 65.7 ± 23.9 | 39.0 ± 3.0 | 177.3 ± 100.4 | 35.5 ± 19.9 | ||
| Pvalue§ | 0.068 | 0.069 | 0.205 | 0.692 | 0.026 | 0.028 | ||
| Alleles | E2 (n = 4) | 23.7 ± 14.3 | 120.0 ± 36.2 | 65.7 ± 30.4 | 41.7 ± 7.8 | 275.3 ± 113.5∗,†l | 54.7 ± 22.7∗,† | |
| E3 (n = 68) | 20.8 ± 15.5 | 147.3 ± 39.4†,‡ | 87.7 ± 40.2 | 39.2 ± 5.7 | 174.2 ± 69.6 | 34.8 ± 13.8 | ||
| E4 (n = 8) | 32.1 ± 16.5 | 113.0 ± 15.0 | 59.5 ± 23.2 | 38.7 ± 2.6 | 165.5 ± 87.7 | 33.1 ± 17.4 | ||
| Pvalue§ | 0.152 | 0.029 | 0.099 | 0.661 | 0.029 | 0.031 | ||
|
| ||||||||
| PPARα | Genotypes | Leu/Leu (n = 54) | 26.7 ± 17.6 | 137.9 ± 39.7 | 78.2 ± 38.8 | 40.9 ± 6.5 | 173.2 ± 81.2 | 34.6 ± 16.2 |
| Leu/Val (n = 8) | 23.1 ± 18.3 | 146.9 ± 32.6 | 83.3 ± 31.1 | 40.3 ± 5.7 | 166.1 ± 35.7 | 33.4 ± 6.9 | ||
| P value# | 0.589 | 0.545 | 0.728 | 0.794 | 0.809 | 0.830 | ||
| Alleles | Leu (n = 116) | 26.5 ± 17.5 | 138.5 ± 39.0 | 78.6 ± 38.1 | 40.8 ± 6.4 | 172.7 ± 78.5 | 34.5 ± 15.6 | |
| Val (n = 8) | 23.1 ± 18.3 | 146.9 ± 32.6 | 83.3 ± 31.1 | 40.3 ± 5.7 | 166.1 ± 35.7 | 33.4 ± 6.9 | ||
| P value# | 0.599 | 0.555 | 0.735 | 0.798 | 0.814 | 0.834 | ||
All values are expressed as the mean ± SD in individuals exposed to Leishmania chagasi.
avalues in mg/dL. # P value analyzed by Student t-test; § P value analyzed by ANOVA test with the Student Newman-Keuls posttest. In relation to genotypes: *P < 0.05 versus E3/E3; † P < 0.05 versus E3/E4. In relation to alleles: *P < 0.05 versus E3; † P < 0.05 versus E4; ‡ P < 0.05 versus E2. H−/H− did not have sufficient number to be analyzed (n = 2). Age = 28.0 ± 12.7; TC = 105.0 ± 14.1; LDL-C = 50.0 ± 7.1; HDL-C = 47.5 ± 2.1; TAG = 126.5 ± 9.2; VLDL-C = 25.5 ± 2.1. E4/E4 did not have sufficient number to be analyzed (n = 1). Age = 22.0; TC = 95.0; LDL-C = 41.0; HDL-C = 38.0; TAG = 130.0; VLDL = 26.0. H+ indicates presence and H− indicates absence of the HindIII restriction site. P1 indicates absence and P2 indicates presence of the PvuII restriction site.
Note: Apo E polymorphism results in six genotypes ranking (E2/E2, E2/E3, E2/E4, E3/E3, E3/E4, and E4/E4) and three alleles (E2, E3, and E4). Bold text indicates statistically significant differences.