Table 2.
Biological properties of some fruits with antileukaemic effect.
| Names of fruits | Activity/uses | Human/animal subjects | Results | References |
|---|---|---|---|---|
| Grape seed | (i) Cell death (ii) Apoptosis |
Leukaemic cells | (i) Forces leukaemia cells to commit cell suicide (ii) Activation of the JNK pathway |
Ning et al., 2009 [38] |
|
| ||||
| Pomegranate | (i) Antioxidant (ii) Antileukaemic |
Leukaemia cell lines | The acetonitrile fractions decreased (ATP) levels in all leukaemic cell lines | Dahlawi et al., 2013 [39] |
|
| ||||
| Carrot | Strong source of bioactive chemicals for the treatment of leukaemia | Leukaemia cell lines | Antileukaemic | Zaini et al., 2011 [40] |
|
| ||||
| Ganoderma lucidum | Antitumour | WEHI-3 leukaemic cells (BALB/c mice) | (i) It decreased the weight of spleens as compared with control mice (ii) To increase the percentages of CD3 and CD19 but decrease the percentages of Mac-3 and CD11b markers |
Chang et al., 2009 [41] |
|
| ||||
| Berberis vulgaris (berberine) | (i) Antioxidant (ii) Antimicrobial (iii) Anticancer |
HL-60 & WEHI-3 | (i) Suppress the growth and proliferation of different HL-60 (ii) Induced G1-phase cell cycle arrest (iii) Influence p53 (iv) Anticancer activity against leukaemic cells (WEHI-3) |
Andola et al., 2010 [42] Kulkarni and Dhir 2010 [43] |