Table 1.
Sensitivity and specificity of 18F-FDG PET in the diagnosis of CS.
| Authors | Year | Subjects studied | JMHW guidelines | No. of patients (n) | Fasting time (h) | Sensitivity (%) | Specificity (%) | Comments |
|---|---|---|---|---|---|---|---|---|
| Yamagishi et al. [38] | 2003 | With CS | 1993 | 17 | >5 | 82 | NA | First systemic research |
| Okumura et al. [34] | 2004 | With sarcoidosis | 1993 | 22 | >12 | 100 | 91 | PET is more sensitive than 67Ga scintigraphy |
| Ishimaru et al. [35] | 2005 | With sarcoidosis | 1993 | 32 | >6 | 100 | 82 | Pre-administered heparin |
| Ohira et al. [32] | 2008 | With suspected CS | 1993 | 21 | >12 | 88 | 39 | Comparing 18F-FDG PET and MRI |
| Langah et al. [36] | 2009 | With suspected CS | 1993 | 76 | >18 | 85 | 90 | PET CT with prolonged fasting >18 h |
| Tahara et al. [37] | 2010 | With suspected CS | 2006 | 24 | >12 | 100 | 46→97 | Analysis using the COV improved specificity |
| Manabe et al. [39] | 2013 | With suspected CS | 1993 | 67 | >6 | 96 | 62 | 18F-FDG uptake was related to ECG abnormalities |
| McArdle et al. [40] | 2013 | With suspected CS | 2006 | 134 | >12 | 100 | 83 | With a high-fat, low-carbohydrate diet on the day before PET |
| Blankstein et al. [33] | 2013 | With suspected CS | 1993 | 118 | >3 | 71 | 45 | With a high-fat, high protein, low-carbohydrate diet |
CS: cardiac sarcoidosis, 18F-FDG PET: 18F-fluorodeoxyglucose positron emission tomography, JMHW: Japanese Ministry of Health and Welfare, COV: coefficient of variation.