Table 2.
Genotype and allele frequencies of miR-137 gene rs1625579 polymorphism in schizophrenic patients and controls.
| N | Genotype n (%) | χ 2 | P | Allele n (%) | χ 2 | P | HWE | OR | 95% CI | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TT | GT + GG | T | G | χ 2 | P | ||||||||
| Total | |||||||||||||
| Patients | 611 | 550 (90.02) | 61 (9.98) | 4.409 | 0.036∗ | 1159 (94.84) | 63 (5.16) | 4.971 | 0.026∗ | 0.097 | 0.756 | 1.450a | 1.024–2.054 |
| Control | 628 | 541 (86.15) | 87 (13.85) | 1164 (92.68) | 92 (7.32) | 0.919 | 0.338 | 1.454b | 1.045–2.024 | ||||
| Male | |||||||||||||
| Patients | 397 | 353 (88.92) | 44 (11.08) | 2.275 | 0.131 | 748 (94.21) | 46 (5.79) | 2.562 | 0.109 | 0.377 | 0.539 | 1.375a | 0.908–2.081 |
| Control | 417 | 356 (85.37) | 61 (14.63) | 769 (92.21) | 65 (7.79) | 0.999 | 0.317 | 1.374b | 0.930–2.032 | ||||
| Female | |||||||||||||
| Patients | 214 | 197 (92.06) | 17 (7.94) | 2.240 | 0.135 | 411 (96.03) | 17 (3.97) | 2.548 | 0.110 | 0.366 | 0.545 | 1.629a | 0.856–3.099 |
| Control | 211 | 185 (87.68) | 26 (12.32) | 395 (93.60) | 27 (6.40) | 0.025 | 0.876 | 1.653b | 0.887–3.079 | ||||
aCalculations were performed TT versus GT + GG; bcalculations were performed T versus G; *P < 0.05.
HWE: Hardy-Weinberg equilibrium; OR: odds ratio; 95% CI: 95% confidence interval; nucleotides: G = guanine, T = thymine.