Table 1.
Effect of 4, 8, or 12 weeks of SrRan or vehicle administration on micro-CT analysis of trabecular bone healing a bone defect in adult female rat tibiae.
| Trabecular bone | Treatment | Time of treatment | ||
|---|---|---|---|---|
| 4 weeks | 8 weeks | 12 weeks | ||
| Conn. D (1) | vehicle | 40.56 ± 11.08 | 14.70 ± 4.49 | 22.86 ± 6.74 |
| SrRan | 75.24 ± 15.15 | 50.73 ± 7.64∗ | 74.87 ± 11.62∗ | |
|
| ||||
| TbN (1/mm) | vehicle | 4.38 ± 0.33 | 3.75 ± 0.14 | 3.91 ± 0.16 |
| SrRan | 4.60 ± 0.22 | 4.20 ± 0.10° | 4.41 ± 0.17 | |
|
| ||||
| TbTh (1/mm) | vehicle | 0.066 ± 0.005 | 0.062 ± 0.003 | 0.064 ± 0.005 |
| SrRan | 0.075 ± 0.005 | 0.081 ± 0.002# | 0.082 ± 0.002∗ | |
|
| ||||
| SMI (1) | vehicle | 2.78 ± 0.27 | 3.30 ± 0.24 | 2.88 ± 0.30 |
| SrRan | 2.25 ± 0.28 | 2.14 ± 0.13∗ | 1.91 ± 0.23° | |
Averages ± SEM; Mann-Whitney; °P < 0.05, *P < 0.01, # P < 0.001 versus time-matched vehicle.