9. Comparison 3: phenytoin/diphenylhydantoin versus placebo: anger‐hostility (skewed data).

Study	Outcome	n(Exp)	Mean(Exp)	SD(Exp)	n(Cntrl)	Mean(Cntrl)	SD(Cntrl)	Statistic	Notes
Barratt 1991   300 mg/day	POMS anger‐hostility subscale, change from baseline, at 4 wks	13	No data		13	No data		Scores not significantly reduced from baseline (ANOVA, Geissner‐Greenhouse adjusted; no further details given)	Favours neither condition Completer analysis (no data available)
Barratt 1991   100 mg/day	POMS anger‐hostility subscale, change from baseline, at 4 wks	13	No data		13	No data		Scores not significantly reduced from baseline (ANOVA, Geissner‐Greenhouse adjusted; no further details given)	Favours neither condition Completer analysis (no data available)
Barratt 1997 300 mg/day	POMS anger‐hostility subscale, impulsive subgroup, at 6 wks	30	20.4	No data	30	22.3	No data	Scores not significantly reduced from baseline (ANOVA, Geissner‐Greenhouse adjusted; no further details given)	Favours neither condition (impulsive aggression subgroup)
Barratt 1997 300 mg/day	POMS anger‐hostility subscale, non‐impulsive subgroup, at 6 wks	30	11.2	No data	30	12.5	No data	Scores not significantly reduced from baseline (ANOVA, Geissner‐Greenhouse adjusted; no further details given)	Favours neither condition (non‐impulsive aggression subgroup)
Stanford 2001 300 mg/day	POMS anger‐hostility subscale, at 6 wks	23	8.44	1.32	23	13.39	2.21	F2,42 = 5.78 (repeated measures ANOVA; P = 0.011; significant main effect for condition) Scores significantly reduced from baseline for phenytoin (F1,21 = 22.80; P < 0.001) but not for placebo condition	Favours phenytoin

POMS = Profile of Mood States; wks = weeks