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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Mol Cancer Res. 2014 Jul 17;12(9):1283–1291. doi: 10.1158/1541-7786.MCR-14-0080

Figure 5. NPMRAR suppresses TNF-alpha induced activation of Caspase 3.

Figure 5

Figure 5

Figure 5

Clones were treated with TNF-alpha (10 ng/mL) and cycloheximide (1 ug/mL). Immunoblots of lysates were probed with anti-caspase 3, anti-PARP, and anti-actin antibodies. Arrows indicate bands for Caspase 3, Cleaved PARP, and Actin.

Panel A: Uncleaved Caspase 3 and Activated PARP in NPM-RAR clone 7, compared with parental U937 cells and vector control clone.

Panel B: Uncleaved Caspase 3 and Activated PARP in NPM-RAR clone 10, compared with parental U937 cells and vector control clone.

Panel C: Uncleaved Caspase 3 and Activated PARP in the NPM-RAR clone 11, compared with parental U937 cells and vector control clone.