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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Biochimie. 2014 Jul 9;0:99–109. doi: 10.1016/j.biochi.2014.06.019

Table 2. Unique Sphingolipid and Ceramide Species in Normotensive and Hypertensive Female DBA/2J Aqueous Humor.

Lipid Speciesa Theoretical
m/zb 		m/z Error
(Da)		 Average lipid
amount (pmol
per species/μg
protein)c 		LIPIDMAPS ID PUBCHEM ID HMDB
Accessiond
Sphingomyelin
Normotensive Aqueous Humor
SM(d16:1/16:0)e 675.5 676.0 0.5 2.9 LMSP03010035 123068746
SM(d16:0/22:0) 761.7 762.2 0.5 19.4 LMSP03010063 123068774
Hypertensive Aqueous Humor
SM(d18:1/20:1)e 757.6 758.0 0.4 244.3 LMSP03010059 123068770
SM(d18:0/22:0) 789.7 790.1 0.4 3.6 LMSP03010022 7850656
SM(d16:1/20:1)e 729.6 730.2 0.6 0.5 LMSP03010048 123068759
SM(d16:0/20:0) 733.6 734.3 0.7 36.7 LMSP03010053 123068764
SM(d18:0/24:0) 817.7 818.1 0.4 15.1 LMSP03010024 7850658
SM(d18:1/22:1) 785.7 786.5 0.8 71.6 LMSP03010072 123068783
Sphingoid base
Normotensive Aqueous Humor
(4E,8Z,d18:2) sphingosinee 298.3 297.4 −0.9 2.1 LMSP01080011 74382660
Hypertensive Aqueous Humor
Penaresidin Ae 330.3 330.3 0.0 0.1 LMSP01080045 74382694
Sphingoid base-1-phosphate
Normotensive Aqueous Humor
Sphinganine-phosphate 380.3 380.8 0.5 53.9 LMSP01050002 7850620 HMDB01383
C16 Sphingosine-1-phosphate 350.2 350.7 0.5 2.1 LMSP01050005 123068722
Ceramides
Normotensive Aqueous Humor
Cer(d18:0/18:1(9Z)) 564.5 565.2 0.7 3.4 LMSP02020015 49703627 HMDB11763
Cer(d18:1/18:1(9Z)) 562.5 563.3 0.8 0.1 LMSP02010003 4266351 HMDB04948
SM(d18:0/12:0)e 647.5 648.4 0.9 0.2 LMSP03010079 123068790
SM(d18:0/15:0)e 689.6 690.4 0.8 1.8 LMSP03010091 123068802
Hypertensive Aqueous Humor
SM(d18:0/17:0)e 717.6 718.6 1.0 4.0 LMSP03010046 123068757
SM(d16:1/18:0)e 701.6 702.4 0.8 0.1 LMSP03010042 123068753
SM(d16:1/20:1)e 727.6 728.5 0.9 0.1 LMSP03010048 123068759
SM(d18:1/20:0) 757.6 758.4 0.8 0.1 LMSP03010005 7850648
SM(d18:2/22:1) 781.6 781.9 0.3 7.5 LMSP03010070 123068781
Cer(d18:0/24:1(15Z)) 648.6 649.6 1.0 4.1 LMSP02020011 7850635 HMDB11769
SM(d16:1/22:1) 755.6 755.3 −0.3 4.0 LMSP03010058 123068769
SM(d18:0/20:0) 759.6 760.4 0.8 0.1 LMSP03010021 7850655
SM(d18:0/24:0) 815.7 816.4 0.7 35.0 LMSP03010024 7850658
SM(d18:1/15:0)e 687.5 688.4 0.9 0.1 LMSP03010038 123068749
SM(d18:2/21:0) 769.6 769.1 −0.6 4.1 LMSP03010064 123068775
a

The lipid species identification is based on Lipidmaps database, customized and used as a .csv file for bioinformatic analyses with the MZmine 2.9 program.

b

The theoretical mass by charge ratio (m/z) presented is in positive ion mode [M+H]+ for sphingomyelin and sphingoid base. Whereas negative ion mode [M-H]− has been presented for sphingoid base-1-phosphate and ceramide. Error in Da has been provided from theoretical data.

c

Average standard normalized dataset is presented here. Species that are known bonafide lipids of non-mammalian origin were excluded. However, where the origin in mammalian or human is unclear those entities were retained.

d

The only lipids species in this table found to have an HMDB identifier (HMDB01383, HMDB11763, HMDB04948, HMDB11769), the following details have been reported: Localization: cytoplasm, extracellular, membrane, endoplasmic reticulum. Functions: cell signaling, component of glycosphingolipid metabolism, fuel and energy storage, fuel or energy source, membrane integrity/stability, component of glycerolipid metabolism, component of glycerophospholipid metabolism,component of prostaglandin and leukotriene metabolism, and second messenger.

e

Lipids common to females and males.