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Some well established illnesses related to mtDNA alterations MELAS = mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes; MIDD = maternally inherited diabetes and deafness; MERRF = myoclonic epilepsy with ragged red fibres; LHON = Leber hereditary optic neuropathy; NARP = neuropathy, ataxia, and retinitis pigmentosa; * = m8470_13446del4977 (Kearns-Sayre syndrome).
