Table 2.
Survival analysis of 459 GC patients
| Variables | Median OS (mo) | X2 value | Univariate P value | HR value | Multivariate P value |
|---|---|---|---|---|---|
| Gender | |||||
| Male | 21 | 0.544 | 0.461 | ||
| Female | 20 | ||||
| Age at surgery (years) | |||||
| ≤ 60 | 20 | 0.128 | 0.720 | ||
| > 60 | 23 | ||||
| Tumor location | |||||
| Upper third | 21 | 7.891 | 0.048 | 1.000 (0.898-1.115) | 0.989 |
| Middle third | 18 | ||||
| Lower third | 24 | ||||
| More than 2/3 stomach | 16 | ||||
| Tumor size (cm) | |||||
| < 4.0 | 26 | 4.551 | 0.033 | 0.945 (0.701-1.274) | 0.733 |
| ≥ 4.0 | 20 | ||||
| Lauren classification | |||||
| Intestinal | 26 | 5.774 | 0.056 | ||
| Diffuse | 20 | ||||
| Mixed | 17 | ||||
| Depth of tumor invasion (T stage) | |||||
| T1 | 70 | 44.871 | < 0.001 | 1.559 (1.309-1.855) | 0.001 |
| T2 | 27 | ||||
| T3 | 24 | ||||
| T4 | 12 | ||||
| Number of metastatic lymph nodes (N stage) | |||||
| N0 | 37 | 98.573 | < 0.001 | 1.552 (1.399-1.720) | 0.001 |
| N1 | 23 | ||||
| N2 | 17 | ||||
| N3 | 10 | ||||
| Methylated CpG site count | |||||
| 3 or less | 21 | 5.484 | 0.019 | 0.968 (0.293-3.198) | 0.958 |
| 4 or more | 12 | ||||
| Methylated status of CpG -515 | |||||
| Unmethylated | 21 | 3.866 | 0.049 | 1.257 (0.735-2.147) | 0.389 |
| Methylated | 14 | ||||
| Methylated status of CpG -435 | |||||
| Unmethylated | 22 | 7.465 | 0.006 | 1.554 (0.849-2.843) | 0.266 |
| Methylated | 12 | ||||
| Methylated status of CpG -430 | |||||
| Unmethylated | 21 | 4.362 | 0.037 | 0.839 (0.302-2.335) | 0.764 |
| Methylated | 15 | ||||