Table 1.

Clinicopathological characteristics of mCRC patients and their correlation to expression levels of OAT2 and OCT2

Variables	N	OAT2		OCT2
		High (%)	P value	High (%)	P value
Age
< 60	31	11 (35)	0.59	18 (58)	0.48
≥ 60	59	21 (36)		36 (61)
Gender
Male	58	20 (34)	0.48	32 (55)	0.15
Female	32	12 (38)		22 (69)
Primary tumor site
Colon	62	21 (34)	0.40	36 (58)	0.38
Rectum	28	11 (39)		18 (64)
Histological differentiation
Well/moderate	85	29 (34)	0.24	51 (60)	0.69
Poor/mucinous	5	3 (60)		3 (60)
Depth of invasion
pT2/pT3	45	14 (31)	0.26	22 (49)	0.03a
pT4	45	18 (40)		33 (73)
Lymph node metastasis
pN0/pN1	50	17 (34)	0.45	31 (62)	0.41
pN2	40	15 (38)		23 (58)
Lymphatic invasion
ly0/ly1	20	8 (40)	0.41	14 (70)	0.22
ly2/ly3	70	24 (34)		40 (57)
Venous invasion
v0/v1	24	8 (33)	0.50	17 (71)	0.15
v2/v3	66	24 (36)		37 (56)

^aStatistically significant.

mCRC: metastatic colorectal cancer; OAT2: organic anion transporter 2; OCT2: organic cation transporter 2.