Table 5.
Multivariate analysis of predictive factors for PFS in patients with mCRC treated with FOLFOX-based chemotherapy
| Variables | HR | 95% CI | P value |
|---|---|---|---|
| OTR | |||
| Poor vs. Good | 0.91 | 0.55-1.49 | 0.69 |
| OAT2 expression | |||
| Low vs. High | 0.68 | 0.41-1.13 | 0.14 |
| OCT2 expression | |||
| Low vs. High | 0.57 | 0.35-0.95 | 0.03a |
a
Statistically significant.
CI: confidence interval; FOLFOX: 5-fluorouracil/leucovorin/oxaliplatin; HR: hazard ratio; mCRC: metastatic colorectal cancer; OAT2: organic anion transporter 2; OCT2: organic cation transporter 2; OTR: objective tumor response; PFS: progression-free survival.