Table 7.
Multivariate analysis of predictive factors for combined good OTR and long PFS in mCRC patients treated with FOLFOX-based chemotherapy
| Variables | OR | 95% CI | P value |
|---|---|---|---|
| Primary tumor site | |||
| Colon vs. Rectum | 2.47 | 0.64-9.54 | 0.19 |
| Depth of invasion | |||
| pT2/pT3 vs. pT4 | 1.92 | 0.62-5.90 | 0.26 |
| OAT2/OCT2 | |||
| High/high vs. Non-high/higha | 5.45 | 1.65-18.03 | 0.006b |
a
Tumors with low levels of at least one of OAT2 and OCT2.
b
Statistically significant.
CI: confidence interval; FOLFOX: 5-fluorouracil/leucovorin/oxaliplatin; mCRC: metastatic colorectal cancer; OAT2: organic anion transporter 2; OCT2: organic cation transporter 2; OR: odds ratio; OTR: objective tumor response; PFS: progression-free survival.