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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Biochem Pharmacol. 2014 Aug 15;91(3):312–322. doi: 10.1016/j.bcp.2014.08.006

Fig. 3.

Fig. 3

Effects of transition metal ions on the cytotoxic activity of triapine and Dp44mT measured using growth inhibition assays. Panels A to F, HL-60 cell were continuously exposed to a fixed concentration of triapine or Dp44mT in the presence of various concentrations of metal ions for 3 days. To measure counteracting action of metal ions, the maximum inhibitory concentrations (0.8, 3.2, and 0.01 µM) of triapine, PT and Dp44mT, respectively, were employed. To measure potentiating action of metal ions, the minimum inhibitory concentrations (0.001 and 0.002 µM) of Dp44mT and P44mT, respectively, were employed. Each metal ion, freshly prepared in H2O at 100 mM, was added to medium prior to chelator. Standard deviation (SD) bars in the figures are omitted for clarity, as values of IC50 (the mean) ± SD are provided in the tables.