Methods	Pill count Follow up at 8 months
Participants	n = 29 high CHD risk 100% male Mean age 49 Participants subgroup of FAT study
Interventions	Niacin 1000mg twice daily (IVG (intervention group)) versus Niacin 500 mg four times daily (CG (control group)) Both groups were on triple therapy consisting of niacin , lovastatin (20mg twice daily) and colestipol (10gr twice daily)
Outcomes	ADHERENCE mean adherence : 96% (IVG) versus 85% (CG) difference in mean adherence between groups: 11% p = 0.01 SERUM LIPIDS Endpoints compared Significant difference in total cholesterol : 158 mg/dl (IVG) versus 172 mg/dl (CG) p< 0.05 Significant difference in LDL 85 mg/dl (IVG) versus 98 mg/dl (CG) p<0.005 Significant difference in LDL/HDL ratio 1.66 (IVG) versus 1.83 (CG) p<0.02 ( provided retrospectively by author as accidentally omitted in paper). Recalculation not performed due to missing standard deviations. ADVERSE EFFECTS Less flushing reported in IVG 14/29 patients without flushing (IVG) versus 6/29 (CG) p reported as < 0.005 patient preference higher in IVG (21/29 versus 4/29, p less than 0.02)
Notes	crossover design, results have to be considered with caution (see ’limitation of this review’) subgroup of bigger trial high to moderate risk of bias Some issues about the data (omission of p-value) were clarified and confirmed in helpful correspondence with the author
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear