Methods	Self reported adherence via questionnaire at 6 months expressed as percentage of patients taking medication as prescribed
Participants	n = 4548 (3635 in IVG / 913 in CG) 13100 initially recruited (10335 in IVG / 2765 in CG), response rate only 35% (35% in IVG / 33% in CG) Patients with high risk of MI Primary care setting mostly (90%) 49% male patients in IVG / 47% in CG Mean age 57 years in IVG/ 58 years in CG USA
Interventions	Telephone reminders and early postal reminders in IVG. Both IVG and CG were started on pravastatin (dose not reported), received lifestyle modification advice by their physician and were sent late postal reminders
Outcomes	According to the authors, there were no significant difference in adherence between IVG and CG. 79.7% of patients in the IVG took their medication as prescribed compared to 77.4% of patients in the CG. Reporting of side effects in patients who had terminated their medication were similar in IVG and CG (5.5% versus 5.3%) P-values, standard deviations and power calculations were NOT reported
Notes	The outcome might have been contaminated by sending late postal reminders to patients belonging to the control group. Self report data remained unclear and could not be retrieved from the author of the study. Overall high risk to bias.
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Yes	A - Adequate