Figure 7. Schematic representation of the proposed role of renin in HIV replication.

Interaction of renin with (P)RR leads to binding of (P)RR to PLZF and its translocation to the nucleus. The PLZF-activated PI3K pathway enhances NF-κB activity, resulting in its binding to the LTR promoter site and thus advancing the propagation of the Gag polyprotein. Both renin and Hpr cleave the Gag polyproteins which results in the generation of proviral proteins, including p24.