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. 2014 Aug 22;3(9):821–831. doi: 10.1242/bio.20148326

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — Left panel: confocal sections of heterozygous (+/−) and homozygous (−/−) PDCD2 knockout 3.5 dpc embryos stained for DNA (Hoechst, blue), cortical actin (Phalloidin, red) and p53 (green); right panel: quantification of percentage nuclear p53 cells per embryo (TCN quantified based on Hoechst staining). Homozygous knockout embryos contain significantly more nuclear p53 cells (average 80%, N = 4) than WT (average 11.6%, N = 11, p = 7.E−5 by t test) and heterozygous embryos (average 7.7%, N = 4, p = 9.E−8 by t test). Scale bars: 50 µm.