Skip to main content
. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Mol Psychiatry. 2013 May 28;18(10):1077–1089. doi: 10.1038/mp.2013.71

Figure 4. Prickle2−/− decreases miniature excitatory post synaptic current frequency and dendritic complexity in cultured primary hippocampal neurons.

Figure 4

(a–c) Miniature excitatory post synaptic currents (mEPSCs) in primary hippocampal cultured neurons. Representative tracings from Pk2+/+ and Pk2−/− neurons (a). mEPSC frequency (***p<0.001) and amplitude (***p<0.001) are significantly reduced in Pk2−/− neurons (b). Cumulative probability plot (c) (d,e)In vitro Sholl analysis. Representative images of Pk2+/+(GFP), Pk2−/−(GFP), or Pk2−/−(hPk2-GFP) transfected cultured primary hippocampal neurons (a). Total intersections for Pk2−/− neurons are reduced relative to Pk2+/+ neurons (*p=0.017) (d). hPk2-GFP overexpression in Pk2+/+ neurons increases dendritic complexity (**p<0.001) and reverses Pk2−/− deficits (**p=0.002) (e). T-test with Bonferroni correction for (e). T-test for (b) Error Bars represent ± S.E.M. See methods for all n values.