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. Author manuscript; available in PMC: 2015 Aug 15.
Published in final edited form as: Biochem J. 2014 Aug 15;462(1):163–171. doi: 10.1042/BJ20140220

Figure 1. Biological role of AKR1D1 (A and B) and chemical structures of the steroid substrates tested.

Figure 1

(A) Steroid hormones are metabolized by the concerted actions of AKR1D1 and AKR1C enzymes. S, steroid hormone. (B) AKR1D1 is responsible for the 5β-reduction in all pathways for the synthesis of primary bile acids cholic acid and chenodeoxycholic acid. R1, -H or -OH; R2, -CH3 or -COOH. (C) All substrates are similar in chemical structure and have an identical A-ring, where the reaction occurs.