Abstract
In the Cornett strain of mice, water diuresis did not prevent hematogenous production of pyelonephritis by Staphylococcus aureus. Increased fluid intake did not affect the numbers of organisms deposited in the kidneys or the rate of growth during the first 4 hr after inoculation. Drinking the glucose solution did not enhance bacterial proliferation within the renal parenchyma. Subcutaneous injection of saline to supplement for interruption of drinking after inoculation reduced the numbers of organisms recovered in the kidneys but not sufficiently to prevent production of pyelonephritis. Incorporating penicillin as a marker indicated that fluids administered by subcutaneous injections were rapidly delivered to the kidneys. Combining diuresis with treatment did not influence the rapidity of delivery of antimicrobial to the kidneys or the length of time that it was present in the renal homogenate.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ANDRIOLE V. T., EPSTEIN F. H. PREVENTION OF PYELONEPHRITIS BY WATER DIURESIS: EVIDENCE FOR THE ROLE OF MEDULLARY HYPERTONICITY IN PROMOTING RENAL INFECTION. J Clin Invest. 1965 Jan;44:73–79. doi: 10.1172/JCI105128. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Andriole V. T. Acceleration of the inflammatory response of the renal medulla by water diuresis. J Clin Invest. 1966 Jun;45(6):847–854. doi: 10.1172/JCI105400. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Andriole V. T. Effect of water diuresis on chronic pyelonephritis. J Lab Clin Med. 1968 Jul;72(1):1–16. [PubMed] [Google Scholar]
- CHERNEW I., BRAUDE A. I. Depression of phagocytosis by solutes in concentrations found in the kidney and urine. J Clin Invest. 1962 Oct;41:1945–1953. doi: 10.1172/JCI104652. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Freedman L. R. Experimental pyelonephritis. 13. On the ability of water diuresis to induce susceptibility to E. coli bacteriuria in the normal rat. Yale J Biol Med. 1967 Feb;39(4):255–266. [PMC free article] [PubMed] [Google Scholar]
- Furtado D., Freedman L. R. Experimental pyelonephritis. XVI. Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus infections in mice and the effect of "water diuresis". Yale J Biol Med. 1970 Dec;43(3):177–193. [PMC free article] [PubMed] [Google Scholar]
- Furtado D., Gorrill R. H. In-vivo effectiveness of the antibiotic colistin in preventing growth of Pseudomonas aeruginosa. J Pathol Bacteriol. 1968 Jul;96(1):65–76. doi: 10.1002/path.1700960108. [DOI] [PubMed] [Google Scholar]
- Gorrill R. H., Klyhn K. M., McNeil E. M. The initiation of infection in the mouse kidney after intravenous injection of bacteria. J Pathol Bacteriol. 1966 Jan;91(1):157–172. doi: 10.1002/path.1700910120. [DOI] [PubMed] [Google Scholar]