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. Author manuscript; available in PMC: 2015 Sep 4.
Published in final edited form as: Cell Stem Cell. 2014 Aug 14;15(3):350–364. doi: 10.1016/j.stem.2014.06.018

Figure 7. Dnmt3b isoform expression and tumor-suppressor role in HSCs.

Figure 7

(A) RNA-SEQ expression of Dnmt3b isoforms in control (Ctl) and 3aKO HSCs. Exons 21 and 22 encoding the methyltransferase domain of Dnmt3b1 are reduced in 3aKO HSCs. (B) Ratio of Dnmt3b isoform expression in Ctl and 3aKO HSCs. (C) Frequencies of genetic mutations in DNMT3A and DNMT3B in a range of tumors extracted from the COSMIC database. (D) Overlap of DNMT3 mutations in patients with endometrial and colon cancer in COSMIC database.