Table 4.

Hazard Ratios for Univariate Analyses of Baseline and Rate of Change in Cognitive Test Scores in Relation to Onset of Clinical Symptoms

	Baseline Test Scores		Time-Dependent Rate of Change in Scores
Cognitive Test	Hazard Ratio* (95% CI)	p-value	Hazard Ratio* (95% CI)	p-value
Logical Memory Immediate	0.59 (0.44-0.80)	0.0005	0.58 (0.36-0.93)	0.024
Logical Memory Delayed	0.48 (0.36-0.65)	0.0001	0.54 (0.34-0.86)	0.009
Logical Memory % Retention	0.56 0.44-0.71	0.0001	0.54 (0.38-0.76)	0.001
Paired Associate Immediate	0.53 (0.41-0.70)	0.0001	0.37 (0.24-0.57)	0.001
Paired Associate Delayed	0.63 (0.49-0.82)	0.0004	0.63 (0.43-0.92)	0.016
Rey Figure Recall	0.62 (0.46-0.82)	0.0008	0.49 (0.38-0.63)	0.001
Block Design Subtest	0.53 (0.38-0.74)	0.0001	0.40 (0.19-0.83)	0.014
Boston Naming Test	0.57 (0.43-0.74)	0.0001	0.69 (0.55-0.85)	0.001
Digit Symbol Test	0.41 (0.29-0.58)	0.0001	0.47 (0.35-0.64)	0.001

^*The hazard ratios are for standardized scores (adjusted for age at baseline and education), and are presented per one standard deviation increase in each cognitive test.

Abbreviations: CI, confidence interval