Table 5.

Hazard Ratios for Univariate Analyses of Baseline and Rate of Change in Cognitive Test Scores and ApoE-4 Status in Relation to Onset of Clinical Symptoms

	Baseline Test Scores		Time-Dependent Rate of Change in Scores
Cognitive Test	Hazard Ratio* (95% CI)	p-value	Hazard Ratio* (95% CI)	p-value
Logical Memory Immediate	0.61 (0.47-0.81)	0.001	0.56 (0.36-0.89)	0.014
ApoE-4	2.35 (1.32-4.17)	0.004	2.25 (1.31-3.87)	0.003
Logical Memory Delayed	0.51 (0.39-0.68)	0.001	0.53 (0.33-0.83)	0.006
ApoE-4	2.18 (1.24-3.85)	0.007	2.12 (1.23-3.64)	0.007
Logical Memory % Retention	0.59 (0.46-0.75)	0.001	0.55 (0.40-0.76)	0.001
ApoE-4	1.98 (1.14-3.45)	0.015	1.78 (1.04-3.05)	0.036
Paired Associate Immediate	0.55 (0.42-0.70)	0.001	0.38 (0.25-0.60)	0.001
ApoE-4	2.39 (1.35-4.26)	0.003	1.87 (1.05-3.32)	0.033
Paired Associate Delayed	0.64 (0.52-0.79)	0.001	0.64 (0.45-0.93)	0.020
ApoE-4	2.77 (1.56-4.91)	0.001	2.31 (1.34-3.96)	0.002
Rey Figure Recall	0.57 (0.43-0.75)	0.001	0.46 (0.36-0.61)	0.001
ApoE-4	2.75 (1.56-4.84)	0.001	2.74 (1.65-4.55)	0.001
Block Design Subtest	0.54 (0.40-0.74)	0.001	0.40 (0.19-0.82)	0.013
ApoE-4	2.35 (1.35-4.07)	0.002	2.16 (1.28-3.65)	0.004
Boston Naming Test	0.63 (0.51-0.78)	0.001	0.68 (0.55-0.85)	0.001
ApoE-4	2.00 (1.16-3.43)	0.013	1.80 (1.06-3.06)	0.031
Digit Symbol Test	0.44 (0.31-0.61)	0.001	0.47 (0.34-0.67)	0.001
ApoE-4	2.01 (1.17-3.47)	0.012	1.94 (1.18-3.20)	0.009

^*The first line for each cognitive test is the hazard ratio for the standardized scores of each cognitive test, adjusted by - baseline age, education and ApoE-4 status (i.e., ApoE-4 positive or ApoE-4 negative). The second line for each cognitive test is the hazard ratio, comparing those who were ApoE-4 positive to those who were ApoE-4 negative, adjusted by - the standardized scores of the cognitive test, baseline age and education.

Abbreviations: CI, confidence interval