Methods	Six-week randomised, double-blind study.
Participants	Outpatients fulfilling DSM-III criteria for current major depressive disorder, with a score between 18 and 25 on the HDRS-21. Age range: 18-65 years old. Exclusion criteria: organic brain disease, history of seizures, serious illness, including cardiovascular, hepatic, renal, respiratory, hematologic, hyperthyroidism, history of severe allergy or multiple drug reaction, history (less than 1 year) of drug and alcolhol abuse, concurrent administration of psychotropic drugs (a part from benzodiazepines), MAOI within 2 weeks, serious suicidal risk, pregnancy, lactation
Interventions	Fluoxetine: 71 participants. Clomipramine: 72 participants. Fluoxetine dose: 20 mg/day. Clomipramine dose: 75 mg/day.
Outcomes	Hamilton Rating Scale for Depression (HDRS-21)
Notes	Funding: unclear
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear