| Methods | Six-week randomised, double-blind study. | |
| Participants | Outpatients fulfilling DSM-III criteria for major depressive disorder, with a score of at least 18 on the HDRS-17. Age range: 18-75 years old. Exclusion criteria: serious medical disease, suicidal patients, history of alcohol or substance abuse, treatment resistant depression, bipolar mood disorder, use of antidepressants in the previous 2 weeks and fluoxetine in the previous 6 weeks |
|
| Interventions | Fluoxetine: 20 participants. Doxepine: 20 participants. Fluoxetine dose range: 20-60 mg/day. Doxepine dose range: 75-225 mg/day. |
|
| Outcomes | Hamilton Rating Scale for Depression (HDRS-17) | |
| Notes | Funding: by industry | |
| Risk of bias | ||
| Item | Authors’ judgement | Description |
| Allocation concealment? | Unclear | B - Unclear |
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