Methods	Six-week randomised, double-blind study.
Participants	Patients fulfilling DSM-III-R criteria for major depression, with a score of at least 22 on the MADRS. Age range: 18-70 years old. Exclusion criteria: concurrent treatment for depressive illness, use of other drugs with psychopharmacological effect, serious risk of suicide, significant cardiac, renal or hepatic disease, pregnancy, lactation, absence of contraception
Interventions	Fluoxetine: 51 participants. Dothiepin: 56 participants. Fluoxetine dose: 20 mg/day. Dothiepine dose range: 75-150 mg/day.
Outcomes	Hamilton Rating Scale for Depression, Montgomery and Asberg Scale for Depression, BPRS, CGI
Notes	Funding: by industry
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear