Methods	Five-week randomised double-blind study.
Participants	Outpatients with diagnosis of neurotic or reaction depressive disorder on the ICD, with a score of at least 17 on the HDRS. Age range: 18-65 years old. Exclusion criteria: suicidality, severe organic disease, diabetes mellitus, glaucoma, hyperthyroidsm, pregnancy, hypersensitivity to drug, abnormal liver values, organic psychosis, schizophrenia, psychopathy, addiction to alcohol or drugs, seizures
Interventions	Fluoxetine: 20 participants. Nomifensine: 20 participants. Fluoxetine dose: 40 mg/day. Nomifensine dose: 150 mg/day. Chloral hydrate or benzodiazepines for sleep were allowed.
Outcomes	Hamilton Rating Scale for Depression, CGI, Symptom Check List of Taneri, PGI, Zung Depression Scale
Notes	Funding: unclear
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear