Methods	Eight-week double-blind, randomised study.
Participants	Outpatients with a diagnosis of depressive episode less than 2 months duration, according to DSM-III criteria, with a minimum score of 25 on the MADRS. Age range: 18-65 yeras old. Exclusion criteria: absence of resistance to mianserin or fluoxetine, absence of associated psychotropic treatment, with the exception of prazepam (40 mg/day)
Interventions	Fluoxetine: 33 participants. Mianserin: 32 participants. Fluoxetine dose range: 20-40 mg/day. Mianserin dose range: 60-90 mg/day.
Outcomes	Hamilton Rating Scale for Depression, Hamilton Rating Scale for Anxiety, Montgomery and Asberg Scale for Depression (MADRS)
Notes	Funding: by industry
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear