Methods	Six-week randomised, double-blind multicentre study.
Participants	Inpatients fulfilling DSM-III-R criteria for major depression, with a score of at least 24 on the MADRS. Age range: 18-65 years old. Exclusion criteria: pregnancy or nursing, severe concomitant physical disease, severe risk of suicide, abuse of alcohol or illecit drugs, schizophrenia or psychosis, organic brain syndrome, hystory of serious allergic drug reaction, treatment with any investigational compound during the previous 6 months, lithium or ECT in the previous 3 months, depot neuroleptics in th previous month, MAOI or oral neuroleptics in the previous 2 weeks, present use of oral anticoagulant or psychotropic drug (except chloral hydrate: 500 mg for sleep)
Interventions	Fluoxetine: 87 participants. Paroxetine: 89 participants. Fluoxetine dose: 20 mg/day. Paroxetine dose: 20 mg/day.
Outcomes	Montgomery and Asberg Scale for Depression (10 items), HAM-A (14 items), Hospital Anxiety and Depression (14 items), CGI-S
Notes	Funding: by industry
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear