Comparison 1.
Fluoxetine vs TCAs
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Failure to respond - HDRS (−50%) | 21 | 2040 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.95 [0.80, 1.14] |
| 1.1 Fluoxetine vs Amitriptyline | 9 | 700 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 1.02 [0.74, 1.38] |
| 1.2 Fluoxetine vs Clomipramine | 1 | 94 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.64 [0.28, 1.44] |
| 1.3 Fluoxetine vs Desipramine | 1 | 58 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 1.11 [0.38, 3.25] |
| 1.4 Fluoxetine vs Dothiepine | 2 | 144 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 2.09 [1.08, 4.05] |
| 1.5 Fluoxetine vs Doxepine | 1 | 40 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 1.0 [0.29, 3.49] |
| 1.6 Fluoxetine vs Imipramine | 6 | 821 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.80 [0.61, 1.06] |
| 1.7 Fluoxetine vs Lofepramine | 1 | 183 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.99 [0.55, 1.77] |
| 2 End-point score on HDRS | 46 | 3224 | Std. Mean Difference (IV, Random, 95% CI) | 0.07 [−0.06, 0.20] |
| 2.1 Fluoxetine vs Amiptriptyline | 17 | 958 | Std. Mean Difference (IV, Random, 95% CI) | 0.12 [−0.07, 0.31] |
| 2.2 Fluoxetine vs Clomipramine | 5 | 372 | Std. Mean Difference (IV, Random, 95% CI) | −0.10 [−0.31, 0.10] |
| 2.3 Fluoxetine vs Desipramine | 3 | 121 | Std. Mean Difference (IV, Random, 95% CI) | 1.25 [−1.28, 3.78] |
| 2.4 Fluoxetine vs Dothiepine | 4 | 266 | Std. Mean Difference (IV, Random, 95% CI) | 0.16 [−0.27, 0.59] |
| 2.5 Fluoxetine vs Imipramine | 13 | 1123 | Std. Mean Difference (IV, Random, 95% CI) | −0.03 [−0.23, 0.16] |
| 2.6 Fluoxetine vs Lofepramine | 1 | 183 | Std. Mean Difference (IV, Random, 95% CI) | 0.13 [−0.16, 0.42] |
| 2.7 Fluoxetine vs Nomifensine | 1 | 28 | Std. Mean Difference (IV, Random, 95% CI) | −0.37 [−1.12, 0.38] |
| 2.8 Fluoxetine vs Nortriptyline | 1 | 154 | Std. Mean Difference (IV, Random, 95% CI) | −0.12 [−0.44, 0.20] |
| 2.9 Fluoxetine vs Trimipramine | 1 | 19 | Std. Mean Difference (IV, Random, 95% CI) | 0.47 [−0.44, 1.39] |
| 3 Failure to complete - Total | 47 | 4136 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.78 [0.68, 0.89] |
| 3.1 Fluoxetine vs Amitriptyline | 16 | 1012 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.64 [0.47, 0.85] |
| 3.2 Fluoxetine vs Clomipramine | 2 | 263 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.66 [0.38, 1.14] |
| 3.3 Fluoxetine vs Desipramine | 2 | 104 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.45 [0.17, 1.19] |
| 3.4 Fluoxetine vs Dothiepine | 5 | 478 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 1.44 [0.98, 2.12] |
| 3.5 Fluoxetine vs Doxepine | 4 | 323 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.81 [0.50, 1.31] |
| 3.6 Fluoxetine vs Imipramine | 13 | 1285 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.79 [0.63, 0.99] |
| 3.7 Fluoxetine vs Lofepramine | 1 | 183 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.51 [0.25, 1.03] |
| 3.8 Fluoxetine vs Nomifensine | 1 | 40 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 4.62 [0.83, 25.62] |
| 3.9 Fluoxetine vs Nortriptyline | 3 | 448 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.68 [0.45, 1.03] |
| 4 Failure to complete - Inefficacy | 32 | 2894 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 1.28 [0.96, 1.69] |
| 4.1 Fluoxetine vs Amitriptyline | 11 | 758 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.99 [0.49, 2.02] |
| 4.2 Fluoxetine vs Clomipramine | 1 | 120 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 7.65 [0.78, 74.93] |
| 4.3 Fluoxetine vs Desipramine | 2 | 104 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 1.02 [0.19, 5.30] |
| 4.4 Fluoxetine vs Dothiepine | 3 | 271 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 1.35 [0.52, 3.49] |
| 4.5 Fluoxetine vs Doxepine | 3 | 283 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 1.70 [0.62, 4.67] |
| 4.6 Fluoxetine vs Imipramine | 11 | 1153 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 1.34 [0.94, 1.93] |
| 4.7 Fluoxetine vs Nortriptyline | 1 | 205 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.41 [0.09, 1.84] |
| 5 Failure to complete - Side Effects | 39 | 3630 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.54 [0.45, 0.64] |
| 5.1 Fluoxetine vs Amitriptyline | 14 | 961 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.40 [0.27, 0.61] |
| 5.2 Fluoxetine vs Clomipramine | 2 | 263 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.34 [0.15, 0.78] |
| 5.3 Fluoxetine vs Desipramine | 2 | 104 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.25 [0.07, 0.92] |
| 5.4 Fluoxetine vs Dothiepine | 5 | 478 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 1.58 [0.90, 2.78] |
| 5.5 Fluoxetine vs Doxepine | 3 | 283 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.80 [0.47, 1.37] |
| 5.6 Fluoxetine vs Imipramine | 11 | 153 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.44 [0.33, 0.58] |
| 5.7 Fluoxetine vs Lofepramine | 1 | 183 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.24 [0.05, 1.07] |
| 5.8 Fluoxetine vs Nortriptyline | 1 | 205 | Peto Odds Ratio (Peto, Fixed, 95% CI) | 0.86 [0.42, 1.77] |