Comparison 2.

Fluoxetine vs Heterocyclics

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Failure to respond - HDRS (−50%)	3		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only
1.1 Fluoxetine vs Maprotiline	2	163	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.92 [0.92, 3.98]
1.2 Fluoxetine vs Mianserin	1	53	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.81 [0.27, 2.36]
2 End-point score on HDRS	8		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
2.6 Fluoxetine vs Maprotiline	5	433	Std. Mean Difference (IV, Random, 95% CI)	0.04 [−0.15, 0.23]
2.7 Fluoxetine vs Mianserin	3	128	Std. Mean Difference (IV, Random, 95% CI)	0.43 [−0.38, 1.23]
3 Failure to complete - Total	6		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only
3.1 Fluoxetine vs Maprotiline	4	351	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.75 [0.93, 3.30]
3.2 Fluoxetine vs Mianserin	2	93	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.67 [0.27, 1.70]
4 Failure to complete - Inefficacy	4		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only
4.1 Fluoxetine vs Maprotiline	3	209	Peto Odds Ratio (Peto, Fixed, 95% CI)	3.01 [0.73, 12.41]
4.2 Fluoxetine vs Mianserin	1	53	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.18 [0.40, 11.74]
5 Failure to complete - Side Effects	4		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only
5.1 Fluoxetine vs Maprotiline	3	209	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.54 [0.16, 1.83]
5.2 Fluoxetine vs Mianserin	1	53	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.04 [0.24, 4.64]